DNA nanotechnology: understanding and optimisation through simulation

DNA nanotechnology: understanding and optimisation through simulation

DNA nanotechnology promises to provide controllable self-assembly on the nanoscale, allowing for the design of static structures, dynamic machines and computational architectures. In this article I review the state-of-the art of DNA nanotechnology, highlighting the need for a more detailed understanding of the key processes, both in terms of theoretical modelling and experimental characterisati...

3D DNA Crystals and Nanotechnology

DNA’s molecular recognition properties have made it one of the most widely used biomacromolecular construction materials. The programmed assembly of DNA oligonucleotides has been used to create complex 2D and 3D self-assembled architectures and to guide the assembly of other molecules. The origins of DNA nanotechnology are rooted in the goal of assembling DNA molecules into designed periodic ar...

Supply Chain Management through a combined simulation-optimisation approach

Supply Chain Management (SCM) involves the decision-making related to resources management through the entire Supply Chain (SC), from the initial suppliers to the final customers (Shapiro, 2001). Many of present SCM approaches consider operations research optimisation models, which often assume centralised management and are inadequate to efficiently undertake SC dynamics and uncertainty. On th...

DNA nanotechnology gets real

In the beginning there was the cube. Nadrian Seeman and coworkers at New York University set out in the early 1990s to construct a nanometre scale cube from DNA. The idea was to use the highly sophisticated methods of molecular biology to build DNA into something new and entirely artificial. Linking DNA fragments together by means of hybridisation of overlapping ends followed by ligation, Seema...

Ultrasound in Cancer Treatment through Nanotechnology